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Search Results for " synuclein, alpha "

Targets Recommended: Others Sirtuin

7

抑制剂 & 化合物

2

天然产物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22026	AGK7	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	AGK7 是 sirtuin 2 (SIRT2) 抑制剂。它在体外和帕金森病果蝇模型中均能抑制多巴胺能细胞的凋亡。在帕金森病细胞模型中，它改善了 α-突触核蛋白毒性和修饰的包涵体形态
T40541	α-Synuclein (61-75)
	α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disease (PD).
T62304	Minzasolmin (R)-NPT200-11,UCB0599,DLX-313	Others	Others
	Minzasolmin（DLX-313）是一种 α-突触核蛋白错误折叠抑制剂，可用于研究帕金森疾病。
T76861	Cinpanemab BIIB054	Others	Others
	Cinpanemab (BIIB054) 是一种新型人源单克隆抗体，对 α-突触核蛋白 1-10 位残基具有亲和力。Cinpanemab 可用于研究帕金森及其相关疾病。
T63321	20S Proteasome activator 1	Proteasome	Proteases/Proteasome; Ubiquitination
	20S Proteasome activator 1 是一种 20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。
T19838	Brilliant Blue R250 Acid Blue 83,Brilliant Blue R,Coomassie Brilliant Blue R250,CBBR,Coomassie Brilliant Blue R
	CBBR is an inhibitor of wild type and mutant alpha-synuclein aggregation. CBBR also a modulator of neurotoxicity.
T60042	NPT200-11	Others	Others
	NPT200-11 是一种口服生物利用度和脑穿透性 ASYN 错误折叠和聚集抑制剂。 NPT200-11 可用于突触核蛋白病的潜在病理学研究，包括帕金森病 (PD)、路易体痴呆 (DLB) 和多系统萎缩 (MSA)。

化合物

Cat.No: T22026

Target: Others, Sirtuin

α-Synuclein (61-75)

Cat.No: T40541

Cat.No: T62304

Synonym: (R)-NPT200-11,UCB0599,DLX-313

Target: Others

Cat.No: T76861

Synonym: BIIB054

Target: Others

20S Proteasome activator 1

Cat.No: T63321

Target: Proteasome

Brilliant Blue R250

Cat.No: T19838

Synonym: Acid Blue 83,Brilliant Blue R,Coomassie Brilliant Blue R250,CBBR,Coomassie Brilliant Blue R

Cat.No: T60042

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7441	Cuminaldehyde Cuminic aldehyde,4-异丙基苯甲醛,Cuminal	Endogenous Metabolite	Metabolism
	Cuminaldehyde (Cuminal) 是一种具有抑制 α-突触核蛋白纤颤和细胞毒性作用的天然醛，是一种 Cuminum cyminum 的主要成分。它显示抗癌特性。
T75438	Corynoxine hydrochloride
	Corynoxine hydrochloride 是一种从Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。

天然产物

Cat.No: T7441

Synonym: Cuminic aldehyde,4-异丙基苯甲醛,Cuminal

Target: Endogenous Metabolite

Corynoxine hydrochloride

Cat.No: T75438

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02512	Alpha-Synuclein Protein, Human, Recombinant PD1,α-Synuclein,PARK4,synuclein, α (non A4...	Human	E. coli
	Alpha-Synuclein Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.5 kDa and the accession number is P37840-1.
TMPY-06460	Alpha-Synuclein Protein, Mouse, Recombinant (His) alphaSYN,synuclein, α (non A4 component of...	Mouse	E. coli
	Alpha-Synuclein Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.31 kDa and the accession number is O55042-1.
TMPY-06318	Alpha-Synuclein Protein,Human,Recombinant (H50Q) Human α-Synuclein Protein (H50Q),synuclein...	Human	E. coli
	Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1.
TMPH-03238	Alpha-synuclein Protein, Rat, Recombinant (GST) SNCA	Rat	E. coli
	Alpha-synuclein Protein, Rat, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 41.5 kDa and the accession number is P37377.
TMPH-02419	Alpha-synuclein Protein, Cynomolgus, Recombinant (His & SUMO) SNCA	Cynomolgus	E. coli
	Alpha-synuclein Protein, Cynomolgus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.5 kDa and the accession number is P61142.
TMPH-02418	Alpha-synuclein Protein, Cynomolgus, Recombinant (His) SNCA	Cynomolgus	P. pastoris (Yeast)
	Alpha-synuclein Protein, Cynomolgus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.5 kDa and the accession number is P61142.
TMPJ-00683	SNCA Protein, Mouse, Recombinant NACP,α-synuclein,Non-A beta component of AD amyloid...	Mouse	E. coli
	SNCA Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 KDa and the accession number is O55042.
TMPJ-00684	SNCA Protein, Mouse, Recombinant (His) Snca,Non-A β component of AD amyloid,Non-A4 component of amy...	Mouse	E. coli
	Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important...
TMPH-03098	Alpha-synuclein Protein, Pig, Recombinant (His & Myc) SNCA	Sus scrofa (Pig)	E. coli
	Alpha-synuclein Protein, Pig, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 22.0 kDa and the accession number is Q3I5G7.
TMPJ-00023	SNCA Protein, Human, Recombinant (His) α-Synuclein,Alpha-Synuclein,PARK1...	Human	E. coli
	SNCA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P37840.
TMPY-02759	Kallikrein 6/KLK6 Protein, Human, Recombinant (His) kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bssp,SP59,h...	Human	HEK293 Cells
	KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh...
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...

重组蛋白

Alpha-Synuclein Protein, Human, Recombinant

Cat.No: TMPY-02512

Species: Human

Expression System: E. coli

Alpha-Synuclein Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06460

Species: Mouse

Expression System: E. coli

Alpha-Synuclein Protein,Human,Recombinant (H50Q)

Cat.No: TMPY-06318

Species: Human

Expression System: E. coli

Alpha-synuclein Protein, Rat, Recombinant (GST)

Cat.No: TMPH-03238

Species: Rat

Expression System: E. coli

Alpha-synuclein Protein, Cynomolgus, Recombinant (His & SUMO)

Cat.No: TMPH-02419

Species: Cynomolgus

Expression System: E. coli

Alpha-synuclein Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPH-02418

Species: Cynomolgus

Expression System: P. pastoris (Yeast)

SNCA Protein, Mouse, Recombinant

Cat.No: TMPJ-00683

Species: Mouse

Expression System: E. coli

SNCA Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00684

Species: Mouse

Expression System: E. coli

Alpha-synuclein Protein, Pig, Recombinant (His & Myc)

Cat.No: TMPH-03098

Species: Sus scrofa (Pig)

Expression System: E. coli

SNCA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00023

Species: Human

Expression System: E. coli

Kallikrein 6/KLK6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02759

Species: Human

Expression System: HEK293 Cells

PRKN Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02631

Species: Mouse

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01263

Species: Human

Expression System: E. coli

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